Antiviral
Anti-tumor
CAR T cells based on HH-003 mAb effectively reduce HBV-infected hepatocytes with high specificity. Both cytotoxic and non-cytotoxic mechanisms play a role in the reduction of HBV infection in vivo.
In this paper, we have developed HH-120, an inhalable IgM-like molecule derived from ACE2, the receptor for SARS-CoV-2. HH-120 effectively neutralizes all known variants of SARS-CoV-2 and significantly reduces viral loads in infected hamsters, offering a promising new treatment option for COVID-19 and potentially other emerging coronaviruses.
Report on the Phase 2 clinical trial data of HH-003 in participants with co-infection of HBV and HDV, HH-003 treatment at a dose of 20 mg/kg demonstrates significant decrease of HDV RNA level and increase of ALT normalization, with a good safety profile.
Two clinical trials of the HH-120 nasal spray as postexposure prophylaxis (PEP) for SARS-CoV-2 showed that it is well tolerated and reduces the risk of infection by approximately 70%.
HH-120 was developed as a nasal spray for the early treatment of SARS-CoV-2 infection. The nasal spray shortened viral clearance time by two days and demonstrated a favorable safety profile.
The first report on the Phase 1b clinical trial data for HH-003 in treatment-naïve patients with HBeAg-positive chronic HBV infection. HH-003 demonstrates good safety and antiviral activity.
Report on Bile acid derived NTCP inhibitors.
Report on pathophysiological research on gallbladder abnormalities in mice and human beings with NTCP deficiency.
Report on Cyclosporine A derived NTCP inhibitors.
Report on the findings indicating that enhanced bile acid sulfation serves as a primary mechanism for bile acid detoxification and elimination in both mice and humans with NTCP deficiency.
The first preclinical data for HH-003（2H5-A14）, a novel human monoclonal antibody targeting HBV PreS1. HH-003 effectively neutralizes HBV and HDV infections by inhibiting the binding of PreS1 to NTCP.
Hepatitis D virus can infect mice expressing human NTCP, establishing a convenient small animal model for investigation of HDV.
Report on the molecular determinants that are critical for HBV and HDV entry and for bile salts uptake by NTCP, indicating that bile acids and their derivatives hold the potential for further development into antiviral drugs.
This study revealed molecular determinants restricting mouse NTCP for viral entry of HBV and HDV.
The discovery story of NTCP as a functional receptor for HBV and HDV.
Developed a pH-dependent anti-CD98 antibody using antibody engineering techniques, this specific antibody demonstrated efficient broad-spectrum anti-tumor activity by selectively binding to intra-tumoral CD98 in a pH-dependent manner.
For the first time, a pH-dependent antibody targeting CD47 has been reported. Leveraging the principle that the tumor microenvironment is acidic, a pH-dependent antibody has been developed, which has strong binding affinity to the antigen CD47 under acidic conditions and weak binding affinity under neutral conditions. This reduces non-specific binding to normal tissues, thereby lowering the side effects of the drug.
For the first time, a pH-dependent antibody targeting EGFR has been reported. Leveraging the principle that the tumor microenvironment is acidic, a pH-dependent antibody has been developed, which has strong binding affinity to the antigen EGFR under acidic conditions and weak binding affinity under neutral conditions. This reduces non-specific binding to normal tissues, thereby lowering the side effects of the drug.
Developed a specific antibody targeting the N-terminus of the FGF19, which can effectively exert anti-tumor proliferation effects while avoiding the severe bile acid-related side effects associated with targeting the C-terminus of FGF19.
Developed an Fc-enhanced anti-TIGIT antibody that demonstrates significant anti-tumor effects across various cancer types by enhancing the CD8+ T and NK cell functions, while also depleting the Tregs.
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