CN
Press Release
Huahui Health reported a novel oral small molecule NTCP inhibitor
2024-09-19 15:00:53

Huahui Health (Beijing) Biotechnology Co., Ltd. (HHHBio), a clinical-stage biotech company founded in Beijing, China, focusing on innovative drug development, recently presented preclinical study results of a novel oral small-molecule inhibitor targeting sodium taurocholate co-transporting polypeptide (NTCP) at the 2024 International Hepatitis B Virus (HBV) Meeting held in Chicago, USA. NTCP is a bile acid transporter specifically expressed on hepatocytes and is also a functional receptor protein for hepatitis B virus (HBV) and hepatitis D virus (HDV) to infect hepatocytes.

 

In 2012, Dr. Wenhui Li’s team at the National Institute of Biological Sciences, Beijing (NIBS) discovered that NTCP is a functional receptor for HBV and HDV. With the support of NIBS, HHHBio built upon this scientific discovery, overcoming a series of technical challenges, and ultimately succeeded in developing a novel oral small-molecule inhibitor targeting NTCP, named HH-1270. Preclinical study data show that HH-1270 has favorable pharmacochemical properties, efficacy, and safety, indicating good potential for clinical development. As an orally administered NTCP small-molecule inhibitor, HH-1270 offers several advantages, such as convenience and accessibility, making it an important complement to HHHBio's macromolecule pipeline for treating HBV and HDV. This will strengthen the company's competitive edge in the field. Currently, there are multiple global reports on NTCP small-molecule inhibitors, with the development of HH-1270 being at the forefront.

 

At this conference, HHHBio presented for the first time “A novel oral NTCP inhibitor HH-1270 exhibits favorable properties as a clinical candidate for the treatment of HBV-HDV infection” This work was selected as the "Best Oral Presentation in the New Drug/Therapy Section" by the conference, and was presented by Dr. Yang Liu, a senior scientist at the company, on behalf of the research team.

 

The International HBV Meeting is a top-tier professional international scientific conference initiated by Jesse Summers (Member of the U.S. National Academy of Sciences) and Harold E. Varmus (Nobel Laureate in Medicine and the 14th Director of the U.S. National Cancer Institute). The first meeting was held in 1985 at Cold Spring Harbor, USA, and for nearly 40 years. It has gathered hundreds of experts from around the world annually to discuss the latest advancements in the field. This year, the conference was held from September 11 to September 15 in Chicago, USA. At the conference, Dr. Wenhui Li, the founder of HHHBio, was awarded the “Distinguished Award in Hepatitis B Research”

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Professional consultants, such as auditors, accountants, and lawyers.

 

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