Press Release
Huahui Health Announces Late-Breaking Data for Its Investigational Anti-PreS1 HBV Neutralizing Antibody at the AASLD 2022
2022-11-08 10:25:10
  • HH-003 — the world’s first HBV neutralizing antibody targeting the pre-S1 domain of the HBV large envelope protein, developed by Huahui Health, unveiled its clinical data for the first time  

  • HH-003 demonstrated favorable safety, tolerability, pharmacokinetics and antiviral activity in treatment-naïve, HBeAg-positive chronic HBV infection participants in a randomized, multi-center, double-blind, placebo-controlled, multiple ascending dose Phase Ib study

【Beijing, China – November 8, 2022】– Huahui Health, a Beijing-based, clinical stage biotechnology company focused on discovering and developing virology, hepatology and oncology therapies, announced the results from the Phase Ib first-in-patient study of HH-003, the world’s first anti-PreS1 hepatitis B virus (HBV) neutralizing antibody, in treatment-naïve, HBeAg-positive chronic HBV infected patients at the 2022 American Association for The Study of Liver Diseases (AASLD) annual conference. 

Prof. Jidong Jia M.D., from Beijing Friendship Hospital, Capital Medical University, China, presented the safety, tolerability, pharmacokinetics, and preliminary efficacy data from the HH-003 Phase Ib study at the AASLD 2022. “The discovery of NTCP (sodium taurocholate co-transporting polypeptide) receptor by Prof. Wenhui Li, scientific founder of Huahui Health, generated optimism in the field that a functional cure for hepatitis B may be possible. HH-003 is designed to inhibit the PreS1 domain on HBV particle to block the virus from engaging with NTCP receptor on hepatocytes.” said Prof. Jidong Jia M.D, “HH-003 demonstrated favorable safety profile and antiviral activity in the study. In the immune-active cohort after 3 doses twice a week treatment, we observed significant decrease of HBsAg. We share the same goal with Huahui Health to cure chronic hepatitis B and look forward to generating more clinical data for HH-003.” 

“We are encouraged by the preliminary clinical data demonstrated by HH-003. Patients enrolled in the study are treatment-naïve HBV patients in immune tolerant or clearance,  we observed promising antiviral response in those patients in immune clearance period after 3 doses twice a week treatment and in follow-up visits.” said Prof. Niu Junqi M.D., from the First Hospital of Jilin University, Changchun, China, a primary investigator of the study.

“HH-003 is a ‘first-in-class’ anti-HBV antibody with dual mechanism of action. It can block the viral entry to hepatocytes to break the circle of de novo infection and re-infection in liver. Meanwhile, it can potentially clear the free virions and infected hepatocyte through Fc-dependent immunological effector functions. As of now, HH-003 has 3 Phase II clinical trials in progress to further evaluate its safety and efficacy in hepatitis B & hepatitis D. We’re striving to bring a new therapeutic option for patients in China and across the globe hopefully sooner than expected.” commented Bin Chen, Ph.D., CEO of Huahui Health.

Chronic hepatitis B remains a significant major health problem in many countries and regions. According to the WHO statistics, there are approximately 296 million people infected by HBV worldwide who are at high risk of developing liver cirrhosis and hepatocellular carcinoma (HCC). As of today, there’s no therapeutic options that could achieve a functional cure of chronic hepatitis B.

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1. What data do we collect?

2. Who is the controller of your personal information?

3. How do we collect your personal information?

4. What rights do you have over your personal information?

5. How do we store your data?

6. How long do we keep your personal information?

7. Who do we share your personal information with?

8. Cookies, website and application data.

9. How do we update this privacy statement?

10. Our responsibility for websites that we do not own or control


1. What data do we collect?

The personal information we collect and process may include:

Basic personal information (for example: your first name, last name, gender, age, etc.); contact information (for example: email address, mailing address, phone number and personal information on social media platforms, etc.); information about how you use this website (for example: your IP address or domain name, the duration of visit to this website, which sections of this website you visited, which contents have been browsed, etc.).


2. Who is the controller of your personal information?

Huahui Health Ltd. and its affiliates are the controllers of your personal information.


3. How do we collect your personal information?

Most of the data we collect is directly provided to our company by you. We will collect, process and save relevant data when you conduct the following actions:

When creating an account, registering online on our website, application or system;

Share or use your social media profile to contact us;

Register with us to receive udpate materials;

When voluntarily completing customer questionnaires or providing feedback under customer support services on any of our message boards or by email;

Contact our business representatives;

Contact us for support or provide feedback;

Participate in online activities, such as webcasts;

Respond to any surveys you may choose to participate in;

Share adverse events or medical information queries with us; and participate in online meetings, etc.;

When you browse this website through a browser, the tracking mechanism of the website will automatically save cookie information about your computer type, media access control card, screen resolution, and operating system version.

If you connect your social media account to our website or application, you will share certain personal information in your social media account with us. This may include your name, email address, photo, social media contact list, and any other information that allows us to access when you connect your social media account to our website or application.


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You may have the following rights:

Withdraw your consent to our processing of your personal information for direct marketing purposes;

Ask us to correct information that you believe is inaccurate or incomplete;

Request us to delete your personal information;

Ask us to restrict the processing of your information;

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Our company will safely store your data in the system of a third-party service provider, such as our website hosting service provider.

We adopt security protection measures that comply with industry standards, including the establishment of reasonable system specifications and security technologies to prevent your personal data from being accessed, used, tampered with, destroyed, or lost.

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To the extent permitted by law, we will only retain personal data necessary for our business. The considerations used to determine the retention period include:

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Activity agency

Recruitment agency

Technology vendors who cooperate with us to develop and improve our websites, digital forums and applications;

Media service providers we work with;

Any entity that may acquire us or part of our business or brand;

Suppliers who manage adverse event reports;

Local or foreign regulatory agencies, courts, governments, and law enforcement agencies; and

Professional consultants, such as auditors, accountants, and lawyers.


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